Diazacycloalkanealkylsulfonamide derivatives

ABSTRACT

A diazacycloalkanealkylsulfonamide derivative having the following formula  I!: ##STR1## and pharmacologically acceptable salts thereof. The compounds have antiallergic activity with low antihistaminic activity and low toxicity and are useful as an medicament for preventing and treating diseases such as bronchial asthma, allergic rhinitis, atopic dermatitis, urticaria.

FIELD OF THE INVENTION

This invention relates to novel diazacycloalkanealkylsulfonamide derivatives having excellent antiallergic activity and thereby are useful as an medicament for preventing and treating diseases such as bronchial asthma, allergic rhinitis, atopic dermatitis, urticaria and the like, and pharmacologically acceptable salts thereof.

PRIOR ART

Presently, some kinds of antihistaminic agents or antiallergic agents having diazacycloalkane-skeletal structure have been found, for example, 1- (4-chlorophenyl)phenylmethyl!-4-methylpiperazine generic name: Chlorcyclizine (Merck Index, 11th edition, 2078)!, 1- (4-chlorophenyl)phenylmethyl!-hexahydro-4-methyl-1H-1,4-diazepine generic name: Homochlorcyclizine (Merck Index, 11th edition, 4653)!. Among diazacycloalkanealkylsulfonic acids, it is known that some compounds have accelerating activity of erythrocyte transformation and antiplatelet aggregation activity Japanese Patent First Publication No. 233670/1990!. However, for example, as shown in Experiments hereinafter, a compound of Reference Example 4 did not show an antiallergic activity. Some of diazacycloalkane alkylsulfonamide derivatives are also known Japanese Patent First Publication No. 153280/1987! and the compounds have calcium antagonistic activity and antiallergic activity. However, they have insufficient activity of suppressing passive cutaneous anaphylaxis (PCA).

Antiallergic agents have been used for treating diseases such as bronchial asthma, allergic dermal affection and allergic rhinitis. However, existing antiallergic agents, e.g. ketotifen, have some defects that drowsiness or sedation are caused by central nervous suppressing activity due to their strong antihistaminic side effects. With the object of removing these defects, various studies have been done until now, but no satisfactory result has been obtained.

DETAILED DESCRIPTION OF THE INVENTION

Under the circumstances, the present inventors have intensively studied, and as a resultant, have found that specific diazacycloalkanealkylsulfonamide derivatives have excellent antiallergic activity with low antihistaminic activity and low toxicity, and further they can readily be prepared.

The present invention provides diazacycloalkanealkylsulfonamide derivatives having the following formula I!: ##STR2## wherein R₁ is hydrogen atom, lower alkyl, lower alkoxy, halogen atom, hydroxy, trifluoromethyl, nitro or amino; R₂ is phenyl which may optionally be substituted by 1 to 3 substituents on the phenyl ring selected from lower alkyl, lower alkoxy, halogen atom, hydroxy, trifluoromethyl, nitro and amino, or 2-pyridyl, 3-pyridyl or 4-pyridyl; a is 2 or 3; Y is alkylene; and R₃ and R₄ are the same or different and are each hydrogen atom, lower alkyl, lower hydroxyalkyl or cycloalkyl, or phenyl which may optionally be substituted by 1 to 3 substituents on the phenyl ring selected from lower alkyl, lower alkoxy, halogen atom, hydroxy, trifluoromethyl, nitro and amino! and pharmacologically acceptable salts thereof.

In the above formula I!, the lower alkyl expressed by R₁ denotes alkyl containing 1 to 4 carbon atoms which include methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl and tert-butyl. Lower alkoxy expressed by R₁ denotes alkoxy containing 1 to 4 carbon atoms which include methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy and tert-butoxy. Halogen atoms expressed by R₁ include chlorine, bromine, fluorine and iodine.

Lower alkoxy and halogen atoms as substituents on the phenyl ring in R₂ include the same groups as defined in the above R₁.

Alkylene expressed by Y denotes straight or branched chain alkylene containing 1 to 12 carbon atoms, and preferably to straight chain alkylene particularly containing 3 to 10 carbon atoms, more particularly 4 to 8 carbon atoms. For example, they include methylene, ethylene, propylene, butylene, pentylene, hexylene, heptylene, octylene, nonylene, decanylene, undecanylene and dodecanylene.

Lower alkyl expressed by R₃ and R₄ denotes alkyl containing 1 to 4 carbon atoms which include methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl and tert-butyl. Lower hydroxyalkyl denotes hydroxyalkyl containing 1 to 4 carbon atoms such as hydroxymethyl, hydroxyethyl, hydroxypropyl, hydroxybutyl. Cycloalkyl denotes cycloalkyl containing 3 to 8 carbon atoms which include cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, and cyclooctyl. Lower alkyl, lower alkoxy and halogen atoms as substituents on phenyl ring in R₃ and R₄ include the same groups defined in above R₁.

Preferred compounds of the present invention are the compounds of formula I! wherein R₁ is hydrogen atom, alkyl containing 1 to 4 carbon atoms, alkoxy containing 1 to 4 carbon atoms, halogen atom, hydroxy, trifluorometyl, nitro or amino; R₂ is unsubstituted phenyl, phenyl substituted by 1 to 2 halogen atoms, 2-pyridyl or 4-pyridyl; a is 2; Y is alkylene containing 3 to 10 carbon atoms; and one of R₃ and R₄ is hydrogen atom and the other is hydrogen atom, alkyl containing 1 to 4 carbon atoms, hydroxyalkyl containing 1 to 4 carbon atoms, cycloalkyl containing 3 to 8 carbon atoms, unsubstituted phenyl or phenyl which is substituted by 1 to 3 substituents on the phenyl ring selected from hydroxy and alkoxy containing 1 to 4 carbon atoms; or both of R₃ and R₄ are alkyl containing 1 to 4 carbon atoms.

More preferred are the compounds of formula I! wherein R₁ is hydrogen atom or halogen atom; R₂ is unsubstituted phenyl, phenyl substituted by halogen atom, 2-pyridyl or 4-pyridyl; a is 2; Y is alkylene containing 3 to 10 carbon atoms; and one of R₃ and R₄ is hydrogen atom and the other is hydrogen atom, alkyl containing 1 to 4 carbon atoms, hydroxyalkyl containing 1 to 4 carbon atoms, cycloalkyl containing 3 to 6 carbon atoms or tri(C₁ -C₄ alkoxy)-substituted phenyl; or both of R₃ and R₄ are alkyl containing 1 to 4 carbon atoms.

Particularly preferred are the compounds of formula I! wherein R₁ is meta- or para-halogen atom, particularly chlorine atom or fluorine atom; and R₂ is unsubstituted phenyl, 4-fluorophenyl, 2-pyridyl or 4-pyridyl. Further particularly preferred are the compound of formula I! wherein R₁ is meta- or para-chlorine atom; and R₂ is unsubstituted phenyl, and the compound of the formula I! wherein R₁ is para-fluorine atom; and R₂ is 2-pyridyl.

Pharmacologically acceptable salts of the compounds of the formula I! include acid addition salts and alkali addition salts. The acid addition salts include inorganic acid salts such as hydrochloride, hydrobromide, hydroiodide, sulfate, nitrate, phosphate, etc. and organic salts such as acetate, oxalate, maleate, fumarate, lactate, malate, citrate, tartrate, benzoate, methanesulfonate, ethanesulfonate, benzenesulfonate, etc. The alkali addition salts include alkali metal or alkaline earth metal salts (e.g. sodium, potassium, calcium), ammonium salts, and salts of organic base such as methylamine, ethylamine, dimethylamine, triethylamine, ethanolamine, piperidine, etc.

When the compounds of the formula I! have asymmetric carbon atoms, there exist optical isomers. And these stereoisomers and the mixture thereof are also included in the scope of the present invention.

Novel diazacycloalkanealkylsulfonamide derivatives of the formula I! of the present invention may be prepared by various methods.

That is, the compounds of the formula I! of the present invention may be prepared by a method as shown in the following reaction schemes A, B or C. ##STR3## wherein X refers to halogen (Cl, Br or I); R₁, R₂, R₃, R₄, a and Y are the same as defined above!

All of the methods A, B and C are conducted by subjecting each reactants to condensation reaction in the presence of a dehydrohalogenating agent in a suitable organic solvent. Any organic solvents which do not inhibit the condensation reaction may be used for the condensation and include alcoholic solvents such as methanol, ethanol, isopropanol and n-butanol, aprotic polar solvents such as tetrahydrofuran, dioxane, acetone, acetonitrile, N,N-dimethylformamide, dimethylsulfoxide, chloroform, dichloromethane, tetrachloromethane, diethyl ether and diisopropyl ether, and aromatic hydrocarbon solvents such as benzene, toluene and xylene. The reactions are carried out at a temperature in the range of 0° C. to 200° C. Dehydrohalogenating agents include, for example, inorganic bases such as potassium carbonate, sodium carbonate, potassium hydrogencarbonate, sodium hydrogencarbonate and organic bases such as pyridine and triethylamine.

The compounds of the formula II! used as the starting material may be prepared by a method of the following reaction scheme. ##STR4## wherein each groups are the same as defined above.!

In the above reaction scheme, a piperazine compound of the formula IV! is reacted with sodium halogenoalkylsulfonate VIII! see, Organic Synthesis, collective Vol. 2, p558! in dry dimethylformamide at reflux temperature, or alternatively according to a method disclosed in Japanese Patent First Publication No. 233670/1990, the piperazine compound IV! is reacted with cyclic sulfonic ester IX! to give a sulfonic acid derivative II'!. Thus obtained compound II'! is halogenated to give the compound II!. This halogenation can readily be carried out by a conventional method using a thionyl halide or phosphorus halide as a halogenating agent. Thionyl halide such as thionyl chloride, thionyl bromide can be employed. The halogenation can be carried out by treating the sulfonic acid derivative II'! with the thionyl compound in an excess amount of said thionyl compound or in an solvent such as benzene, toluene, xylene, dichloromethane, chloroform, dimethylformamide or diethyl ether at 0° to 200° C. for 30 minutes to 5 hours to give the compound II!, which reaction is carried out optionally after converting the sulfonic acid derivative to sodium sulfonate or in the presence of tertiary amine such as pyridine, quinoline, dimethylaniline, triethylamine and diisopropylethylamine. Phosphorus halides such as phosphorus trichloride, phosphorus pentachloride, phosphorus tribromide, phosphorus pentabromide and phosphorus oxychloride can be employed. The compound II! can be obtained by using these phosphorus halides under the same conditions as in the reaction using thionyl halide as mentioned above.

The compounds of the formulae IV! and VI! (except a part) are disclosed, for example, in Journal of Pharmaceutical Science, Vol. 67, p900 (1978) and may be prepared by a method of the following reaction scheme. ##STR5##

Pharmaceutical compositions comprising the novel diazacycloalkanealkylsulfonamide derivative of the formula I! or a pharmaceutically acceptable salt thereof as an active ingredient may be administered by both of oral and parenteral routes.

The dosage forms for oral administration include tablets, capsules, powders, fine granules, granules, solutions, syrups, etc. The dosage form for parenteral administration include injections, suppositories, inhalants, eye drops, nasal drops, ointments, patches, etc. These preparations can be prepared with pharmaceutically acceptable additives such as excipients, disintegrators or disintegration auxiliaries, binders, lubricants, coating agents, pigments, diluents, bases, solvents or solubilizing agents, isotonicity agents, pH adjusters, stabilizers, propellants, adhesives.

The preparations for oral administration or for trans-dermal or mucosal administration are prepared by using excipients such as glucose, lactose, D-mannitol, starch and crystalline cellulose; disintegrators or disintegration auxiliaries such as carboxymethyl cellulose, starch and carboxymethyl cellulose calcium; binders such as hydroxypropyl cellulose, hydroxymethyl cellulose, polyvinyl pyrrolidone and gelatin; lubricants such as magnesium stearate and talc; coating agents such as hydroxypropylmethyl cellulose, sugars, polyethylene glycol and titanium oxide; bases such as petrolatum, liquid paraffin, polyethylene glycol, gelatin, kaolin, glycerin, purified water and hard fat; propellants such as furon, diethyl ether and compressed gas; adhesives such as sodium polyacrylate, polyvinyl alcohol, methyl cellulose, polyisobutylene and polybutene; and substrates such as cotton cloth or plastics sheet and the like.

The preparations for injection are prepared by using solvents or solubilizing agents suitable for preparing aqueous injections or injections to be dissolved when used, such as distilled water for injection, saline, propylene glycol; isotonicity agents such as glucose, sodium chloride, D-mannitol, glycerin; pH adjusters such as inorganic and organic acids; or inorganic and organic bases.

The dosage of a compound of formula I! will vary depending on age of patients, severity of diseases, etc. Generally, the dose for oral administration is about 0.1 to 300 mg/day in adult.

Best mode for carrying out the invention

The compounds of this invention are illustrated by the following Experiments, Reference Examples and Examples, but should not be constructed to be limited thereto.

Experiment 1

Activity of suppressing passive cutaneous anaphylaxis (PCA)

Test compounds were examined on their antiallergic activities. Male Wistar rats (weighing 150 to 200 g) were subjected to passive sensitization by intracutaneous injection of a monoclonal anti-DNP antibody to the bilateral regions on the back of the rats, said monoclonal anti-DNP antibody showing 1:1024 of 48 hours homologous PCA (passive cutaneous anaphylaxis) titer, which was diluted to 1000fold with saline and was injected in an amount of 0.1 ml. After 48 hours, 1.0 ml of 0.5 % Evans Blue saline solution containing DNP.BSA (1 mg in protein) was injected through the tail vein to induce allergic reaction. After 30 minutes, the rats were sacrificed by bleeding and the skin of back where dye was leaked out was flayed and put it into 20 ml test tube with ground stopper. Thereto was added 1.0 ml of 1N KOH aqueous solution and then it was allowed to stand at 37° C. in incubator overnight for lysing. To this solution was added 8.3 ml of a mixture of acetone and 0.6N phosphoric acid (13:5) and the mixture was mixed well and then was filtered to remove the insoluble materials. An amount of dye was determined by measuring the absorbance at 620 nm of the filtrate.

The test compounds were administered orally 1 hour before the antigen challenge. Suppression rate was expressed by percentage to the value in control where 0.5% aqueous methylcellulose solution was orally administered.

The results are shown in Table 1 below. As in shown therein, each compound showed PCA suppression activity of about 71 to 98% in a dosage of 10 mg/kg.

                  TABLE 1                                                          ______________________________________                                                  % suppression         % suppression                                   test     of rat PCA   test     of rat PCA                                      compound (10 mg/kg-po)                                                                               compound (10 mg/kg-po)                                   ______________________________________                                         Ex. No.               Ex. No.                                                   3       95.2         101      88.0                                             4       89.0         104      86.7                                            13       73.8         106      90.3                                            19       78.0         107      87.8                                            21       89.7         108      82.2                                            26       71.0         110      88.3                                            29       95.7         113      87.5                                            31       87.2         114      83.5                                            32       86.8         115      73.2                                            34       84.8         116      70.2                                            36       77.5         120      93.4                                            39       83.8         123      83.5                                            42       80.2         124      88.4                                            43       86.5         126      80.8                                            45       84.0         127      90.7                                            48       83.8         128      86.1                                            54       89.2         129      92.2                                            56       94.5         134      87.1                                            57       90.6         135      74.4                                            58       76.5         136      80.2                                            59       96.4         137      75.8                                            61       89.7         141      87.4                                            64       72.5         143      87.8                                            65       74.7         149      97.7                                            66       82.8         150      89.1                                            67       84.1         153      86.2                                            68       94.5         Ref. Ex. 4                                                                              0                                               69       88.3         ketotifen,                                                                              47.4-73.6                                       82       86.8                  (2 mg/kg-po)                                    99       72.1                                                                  ______________________________________                                    

Experiment 2

Antihistaminic activity

Female Hartley guinea pig (weighing 500 to 650 g) were sacrificed and the ileum (length of about 10 to 25 cm) was extracted from the ileocecum to prepare a specimen (length of 3 cm). The specimen was suspended with a load of 0.5 g in a Magnus tube filled with Tyrode (30°±1° C.) under flowing of a mixture of 95% O₂ gas+5% CO₂ gas. After allowing to stand for 60 minutes to make the specimen stable, a histamine (3×10⁻⁷ M) was applied to the specimen at single application. Contraction of the specimen was determined and recorded using isotonic transducer. After repeating application of a histamine to make the contraction constant, a diluted solution of the test compound was applied. Three minutes after the application, a histamine was then added and an activity of suppressing contraction was examined. The results were shown by the molar concentration (M) of the test compound which effected 50% suppression of contraction (EC₅₀ value). The results are shown in Table 2. All compounds of the present invention had antihistaminic activity lower than that of ketotifen which was a reference compound.

                  TABLE 2                                                          ______________________________________                                                  anti-His in           anti-His in                                              extracted             extracted                                       test     ileum        test     ileum                                           compound EC.sub.50 (M)                                                                               compound EC.sub.50 (M)                                   ______________________________________                                         Ex. No.               Ex. No                                                    3       7.6 × 10.sup.-7                                                                        99      1.3 × 10.sup.-6                            4       6.5 × 10.sup.-7                                                                       101      8.1 × 10.sup.-7                           13       3.2 × 10.sup.-7                                                                       104      6.8 × 10.sup.-6                           19       4.6 × 10.sup.-7                                                                       106      4.0 × 10.sup.-7                           21       5.1 × 10.sup.-7                                                                       107      6.2 × 10.sup.-7                           26       3.0 × 10.sup.-7                                                                       108      6.8 × 10.sup.-7                           29       7.5 × 10.sup.-7                                                                       110      5.7 × 10.sup.-7                           31       7.7 × 10.sup.-7                                                                       113      7.1 × 10.sup.-7                           32       8.4 × 10.sup.-7                                                                       114      5.6 × 10.sup.-7                           34       3.3 × 10.sup.-7                                                                       115      7.9 × 10.sup.-7                           36       5.6 × 10.sup.-7                                                                       116      1.2 × 10.sup.-7                           39       8.1 × 10.sup.-7                                                                       120      7.0 × 10.sup.-7                           42       3.3 × 10.sup.-7                                                                       123      3.3 × 10.sup.-7                           43       6.9 × 10.sup.-7                                                                       124      2.0 × 10.sup.-7                           45       7.4 × 10.sup.-7                                                                       126      3.0 × 10.sup.-7                           48       3.5 × 10.sup.-7                                                                       127      4.1 × 10.sup.-7                           54       4.2 × 10.sup.-7                                                                       128      3.2 × 10.sup.-7                           56       4.4 × 10.sup.-7                                                                       129      1.8 × 10.sup.-6                           57       3.9 × 10.sup.-7                                                                       134      5.8 × 10.sup.-7                           58       3.5 × 10.sup.-7                                                                       135      1.1 × 10.sup.-6                           59       2.9 × 10.sup.-6                                                                       136      5.4 × 10.sup.-7                           61       3.1 × 10.sup.-7                                                                       137      2.2 × 10.sup.-6                           64       3.6 × 10.sup.-7                                                                       141      2.1 × 10.sup.-7                           65       4.3 × 10.sup.-7                                                                       143      2.8 × 10.sup.-6                           66       4.2 × 10.sup.-7                                                                       149      3.1 × 10.sup.-7                           67       4.2 × 10.sup.-7                                                                       150      3.5 × 10.sup.-7                           68       3.7 × 10.sup.-7                                                                       153      2.6 × 10.sup.-6                           69       1.5 × 10.sup.-7                                                                       ketotifen                                                                               4.0-5.5 × 10.sup.-9                       82       7.9 × 10.sup.-7                                                 ______________________________________                                    

Experiment 3

Toxicity Test

The test compounds were orally administered to male ICR mice (weighing to 30 g) after fasting overnight. The life or death of these mice was observed for 24 hours. The results were expressed by minimum lethal dose. The results were shown in Table 3. Toxicity of any compounds of the present invention were weaker than that of ketotifen which was a reference compound.

                  TABLE 3                                                          ______________________________________                                                  mouse acute            mouse acute                                             toxicity               toxicity                                       test     (lethal dose) test     (lethal dose)                                  compound (10 mg/kg-po) compound (10 mg/kg-po)                                  ______________________________________                                         Ex. No.                Ex. No.                                                  3       >500           66      >500                                            4       >500           67      >500                                           13       >500           69      >500                                           21       >500           99      >500                                           26       >500          101      >500                                           29       >500          104      >500                                           31       >500          108      >500                                           32       >500          115      >500                                           39       >500          116      >500                                           42       >500          120      >500                                           43       >500          124      >500                                           45       >500          128      >500                                           48       >500          129      >500                                           54       >500          135      >500                                           56       >500          136      >500                                           59       >500          137      >500                                           61       >500          143      >500                                           64       >500          150      >500                                           65       >500          153      >500                                                                  ketotifen                                                                                500                                           ______________________________________                                    

Experiment 4

Mouse Biphasic Allergic Dermal Reaction

Female Balb/c mice (weighing 18 to 25 g) were subjected to passive sensitization by intravenous administration of 1 ml of anti-DNP monoclonal IgE antibody showing 1:1024 of antibody titer. 24 hours after the sensitization, 25 μl of 0.15% dinitrofluorobenzene (DNFB) were applied to both sides of right and left auricles of mouse for inducing allergic reactions. Thickness of auricles were measured using Dial Thickness Gauge before the challenge with DNFB, and 1 and 24 hours after the challenge. And then, increase in thickness of auricles at 1 hour after the challenge (edema caused by immediate allergic reaction) and that at 24 hours after the challenge (edema caused by late allergic reaction) were calculated against the thickness of auricles before the challenge with DNFB, respectively.

Suppression rate was expressed by relative ratio (%) to the value in control in which a solvent was administered.

Test compounds, diphenhydramine which is a existing classical antihistamic drug, amlexanox which is an antiallergic drug and dexamethasone which is a steroidal drug were administered orally (partly intraperitoneally) once before antigen challenge. The results were shown in Table 4.

The above test was performed by using a mouse biphasic allergic dermal reaction model which was a new model see, Sakurai T, Inagaki, N. and Nagai, H Life Sci., 54, PL291-295 (1994)!. In this model, the immediate allergic reaction was induced by mediator release from mast cell at 1 hour after the challenge, and the late allergic reaction with inflammatory cells such as eosinophil (edema after 24 hours) was induced after 24 hours from the challenge.

                  TABLE 4                                                          ______________________________________                                                  mouse biphasic allergic dermal reaction                                                immediate   late                                                       dose    edema (1 hr)                                                                               edema (24 hr)                                     test compound                                                                             mg/kg     suppression (%)                                                                            suppression (%)                               ______________________________________                                         Example 54 0.1           19.0      37.0                                                   1.0           52.4      51.9                                        Example 56 0.1           NE        3.8                                                    1.0           15.8      34.6                                        Example 57 0.1           NE        7.7                                                    1.0           31.6      46.2                                        Example 61 0.1           5.0       37.0                                                   1.0           NE        44.4                                        Example 120                                                                               0.1           26.1      7.1                                                    1.0           56.5      25.0                                        Example 128                                                                               0.1           32.0      36.0                                                   1.0           28.0      40.0                                        Example 143                                                                               0.1           24.0      4.0                                                    1.0           40.0      28.0                                        Example 153                                                                               0.1           24.0      24.0                                                   1.0           56.0      48.0                                        diphenhydramine                                                                           3.0           17.8      NE                                                     10.0          13.3      NE                                                     30.0          53.30     14.3                                        amlexanox  3.0           38.5      12.1                                                   10.0          38.5      NE                                                     30.0          50.0      6.1                                         dexamethasone                                                                             0.1    (i.p.) 32.4      34.3                                                   1.0           32.4      42.9                                                   3.0           11.8      45.7                                        ______________________________________                                          NE : noneffect                                                           

As shown in the above results, diphenhydramine which is a classical antihistamic drug and amlexanox which is a typical mediator release inhibitor suppressed the immediate allergic reaction (edema after 1 hour), but did not suppress the late allergic reaction (edema after 24 hours). On the other hand, the test compounds of Example 54, 56, 57, 61, 120, 128, 143 and 153 showed strong activity of suppressing the late allergic reaction. In addition, dexamethasone which is a steroidal drug also showed the strong activity of suppressing the late allergic reaction.

As shown in the above pharmacological tests, it was found that the compounds of the present invention had strong activity of suppressing PCA and showed obviously weaker antihistaminic activity indicated by activity of suppressing contraction of extracted ileum of guinea pig than the reference compound. Further, as shown in the above toxicity test, any test compounds showed weaker toxicity than the reference compound and therefore they have very high safety. Accordingly, the compounds of the present invention are useful clinically as a medicament and can be continuously administered for a long period of time. And further, as they have activity of suppressing the late allergic reaction, they are useful as a medicament for treating allergic disease, particularly bronchial asthma and atopic dermatitis.

REFERENCE EXAMPLE 1

Preparation of sodium 6-bromohexylsulfonate

To a stirred mixture of dibromohexane (81.0 g), ethanol (120 ml) and water (50 ml) is added dropwise an aqueous solution (50 ml) of sodium sulfite (12.5 g) under reflux over 2 hours. After additional refluxing for 2 hours, the reaction mixture is allowed to cool and unreacted dibromohexane is removed and then the resulting solution is concentrated under reduced pressure. 95% Ethanol (200 ml) is added and the mixture is allowed to cool at room temperature overnight and precipitated crystals are collected by filtration to give the title compound as colorless prisms. The filtrate is concentrated and is allowed to cool overnight and precipitated crystals are collected by filtration to give additional title compound.

First crystals: yield 11.1 g (41.5%), mp.>300° C.

Second crystals: yield 7.0 g (26.2%), mp.>300° C.

REFERENCE EXAMPLE 2

Preparation of (2-fluorophenyl)phenylmethanol and (2-fluorophenyl)phenylmethyl!piperazine:

2-Fluorobenzophenone (15.0 g) is dissolved in ethanol and sodium borohydride (3.8 g) is added in portions and the mixture is stirred for 20 hours. The reacted solution is concentrated under reduced pressure and extracted with chloroform and water to give crude (2-fluorophenyl)phenylmethanol (15.0 g) (quantitative) as colorless liquid.

Then, the crude product (15.0 g) is dissolved in methylene chloride (100 ml), a solution of thionyl chloride (25.0 g) in methylene chloride is added dropwise under ice cooling and the mixture is refluxed for 3 hours. The reacted solution is concentrated under reduced pressure, added dropwise into a solution of piperazine (27.5 g) in isopropanol and refluxed for 24 hours. After concentrating under reduced pressure, the solution is extracted with chloroform and water to give (2-fluorophenyl)phenylmethyl!piperazine (17.5 g, 87%) as pale yellow liquid.

REFERENCE EXAMPLE 3

Preparation of 6- 4-(2-fluorophenyl)phenylmethyl!-1-piperazinyl!hexylsulfonic acid:

(2-Fluorophenyl)phenylmethyl!piperazine (2.0 g), sodium 6-bromohexylsulfonate (5.9 g) and dry dimethylformamide (150 ml) are added to a flask and the mixture is heated and stirred at 180° C. for 16 hours. The solution is concentrated under reduced pressure and recrystallized from ethanol-acetone to give the title compound (2.0 g, 64%) as colorless prisms. mp. 261°-262° C.

REFERENCE EXAMPLE 4

Preparation of 4- 4- 4-fluorophenyl-(2-pyridyl)methyl!-1-piperazinyl!butylsulfonic acid:

After a mixture of 4-fluorophenyl-(2-pyridyl)methyl!piperazine (2.71 g), 1,4-butanesultone (4.08 g) and isobutylmethylketone (60 ml) is heated at reflux temperature for 20 hours, precipitated crystals are collected by filtration and recrystallized from ethanol-acetone to give the title compound (2.91 g, 71.5%). mp. 231°-232° C.

REFERENCE EXAMPLE 5

Preparation of 6-piperazinylhexylsulfonedimethylamine:

1-Benzylpiperazine (3.5 g), sodium 6-bromohexylsulfonate (16.2 g) and dry dimethylformamide (150 ml) are added to a flask and the mixture is heated and stirred at 180° C. for 16 hours. Precipitated crystals are collected by filtration and recrystallized from ethanol-diethyl ether to give 6-(4-benzyl-1-piperazinyl)hexylsulfonic acid (4.36 g, 63.5%) as colorless prisms. mp. 228°-230° C.

To the above sodium salt (4.0 g) is added thionyl chloride (20 ml) under ice cooling and stirred, and then, heated at 50° C. for 30 minutes. After distilling off unreacted thionyl chloride, a solution of dimethylamine in acetonitrile (10% w/w, 20 ml) is added dropwise under ice cooling and stirred at room temperature for 3 hours. After filtering off insoluble materials, the solvent is distilled off to give a brown liquid. The liquid is treated by column chromatography silica gel, chloroform-methanol (100:2)! and the resulting purified material (1.8 g) is dissolved in ethanol and the solution is subjected to catalytic reduction by adding 10% palladium/carbon (1.5 g). The resulting brown liquid is treated by column chromatography silica gel, chloroform-methanol (100:1 )! to give the title compound (1.08 g, 80%) as pale yellow liquid.

EXAMPLE 1 (Method A)

Preparation of 10- 4-(diphenylmethyl)-1-piperazinyl!decanylsulfonamide hydrochloride:

Sodium 10- 4-(diphenylmethyl)-1-piperazinyl!decanylsulfonate (1.0 g) is added to thionyl chloride (10 ml) under ice cooling and the mixture is stirred and then heated at 50° C. for 30 minutes. After distilling off unreacted thionyl chloride, a solution of ammonia in acetonitrile (5% w/w, 20 ml) is added dropwise under ice cooling and stirred at room temperature for 3 hours. After filtering off insoluble materials, the solvent is distilled off to give a brown liquid. The liquid is treated by column chromatography silica gel, chloroform-methanol (20:1)! and the resulting purified material (0.83 g, 77.7%) is converted into hydrochloride by using hydrochloric acid-methanol solution and recrystallized from ethanol-diethyl ether to give the title compound as pale yellow crystals. mp.125°-130° C.

Mass Spectrum (MS): m/z:471 (M⁺);

NMR Spectrum: δ(CDCl₃) ppm: 1.10-2.20 (16H,m), 2.35-2.95 (10H, m), 2.96-3.40 (2H, m), 4.32 (1 H, s), 5.35 (2H, s), 7.18-7.68 (10H, m).

EXAMPLES 2 TO 17

Compounds of Table 5 below are prepared from various starting materials according to the same manner as described in Example 1.

                                      TABLE 5                                      __________________________________________________________________________      ##STR6##                                                                      Ex.                        m p. MS                                             No.                                                                               R.sub.1                                                                           R.sub.2  a  n  aspect                                                                               (°C.)                                                                        (M/Z)M.sup.+                                                                         NMR δ (CDCl.sub.3)                 __________________________________________________________________________                                           ppm                                      2  H                                                                                  ##STR7##                                                                               2  8  pale brown crystals                                                                  135-140                                                                             443   1.16-2.10(16H, m), 2.10-2.86(10H,                                              m), 2.92-3.29(2H, m), 4.27(1H, s),                                             4.54(2H, s), 7.06-7.77(10H, m)           3  4-Cl                                                                               ##STR8##                                                                               2  6  colorless crystals                                                                   112-116                                                                             449   1.12-2.08(8H, m), 2.43-3.53(12H,                                               m)4.28(1H, s), 5.25 (2H,                                                       s)7.01-7.42(9H, m)                       4  4-Cl                                                                               ##STR9##                                                                               2  8  colorless crystals                                                                   105-109                                                                             477   1.02-2.04(12H, m), 2.09-2.68(10H,                                              m)2.79-3.22(2H, m), 4.17(1H,                                                   s)4.40(2H, b), 6.99-7.47(9H, m)          5  4-Cl                                                                               ##STR10##                                                                              2  8  colorless crystals                                                                   153-155                                                                             511   1.07-2.01(12H, m), 2.21-2.87(10H,                                              m)2.89-3.32(2H, m), 4.20(1H,                                                   s)4.43(2H, b), 7.04-7.48(8H, m)          6  4-F                                                                                ##STR11##                                                                              2  8  pale brown crystals                                                                  152-156                                                                             462   1.03-2.01(12H, m), 2.05-2.78(10H,                                              m)2.80-3.25(2H, m), 4.21(1H,                                                   s)4.31-5.01(2H, b), 6.62-8.55(8H,                                              m)                                       7  4-F                                                                                ##STR12##                                                                              2  2  pale yellow crystals                                                                 225-230                                                                             378   2.25-2.70(8H, m), 2.80-3.35(4H,                                                m)4.38(1H, s), 6.75- 8.50(8H, m)         8  4-F                                                                                ##STR13##                                                                              2  3  colorless crystals                                                                   135-140                                                                             392   1.77-2.81(12H, m), 3.17(2H,                                                    t)4.39(1H, s), 4.69(2H,                                                        b) 6.75-8.43(8H, m)                      9  4-F                                                                                ##STR14##                                                                              2  4  pale yellow crystals                                                                 225-230                                                                             406   1.40-2.20(4H, m), 2.20-3.90(12H,                                               m)4.48(1H, s), 5.20- 5.90(2H,                                                  b)6.60-8.36(8H, m)                       10 4-F                                                                                ##STR15##                                                                              2  5  colorless crystals                                                                   165-170                                                                             420   1.10-2.00(6H, m), 2.10-2.70(10H,                                               m)2.85-3.25(2H, m), 4.00-4.70(2H,                                              b)4.34(1H, s), 6.70-8.56(8H, m)          11 4-F                                                                                ##STR16##                                                                              2  6  pale brown crystals                                                                  150-155                                                                             434   1.08-2.09(8H, m), 2.10-2.74(10H,                                               m)3.09(2H, t), 4.41(1H, s)4.79(2H,                                             b), 6.60-8.66(8H, m)                     12 4-F                                                                                ##STR17##                                                                              2  7  colorless crystals                                                                   155-160                                                                             448   1.10-2.00(10H, m), 2.00-2.70(10H,                                              m)2.92-3.27(2H, m), 4.00-4.70(2H,                                              b)4.37(1H, s), 6.70-8.43(8H, m)          13 4-F                                                                                ##STR18##                                                                              2  8  pale brown crystals                                                                  140-150                                                                             462   1.03-2.15(12H, m), 2.18-2.83(10H,                                              m)3.08(2H, t), 4.08- 4.88(2H,                                                  b)4.37(1H, s), 6.68-8.43(8H, m)          14 4-F                                                                                ##STR19##                                                                              2  9  pale brown crystals                                                                  141-145                                                                             476   1.10-2.10(14H, m), 2.12-2.80(10H,                                              m)2.98-3.32(2H, m), 4.47(1H,                                                   s)6.70-8.70(8H, m)                       15 4-F                                                                                ##STR20##                                                                              2  10 pale yellow crystals                                                                 107-112                                                                             490   1.02-2.02(16H, m), 2.07-2.80(10H,                                              m)2.90-3.34(2H, m), 4.44(1H,                                                   s)4.70-5.30(2H, b), 6.42-8.60(8H,                                              m)                                       16 4-F                                                                                ##STR21##                                                                              2  11 pale brown crystals                                                                  79-83                                                                               504   1.05-2.12(18H, m), 2.20-2.96(10H,                                              m)2.97-3.38(2H, m), 4.45(1H,                                                   s)5.02(2H, b), 6.70-8.70(8H, m)          17 4-F                                                                                ##STR22##                                                                              2  12 pale yellow crystals                                                                 114-118                                                                             518   1.07-2.05(20H, m), 2.07-2.80(10H,                                              m)3.15(2H, t), 4.00- 4.85(2H, b),                                              4.44(1H, s), 6.80-8.65(8H,               __________________________________________________________________________                                           m)                                  

EXAMPLES 18 TO 28

Compounds of Table 6 below are prepared from various starting materials according to the same manner as described in Example 1 except using methylamine instead of ammonia.

                                      TABLE 6                                      __________________________________________________________________________      ##STR23##                                                                     Ex.                        m p. MS                                             No.                                                                               R.sub.1                                                                           R.sub.2  a  n  aspect                                                                               (°C.)                                                                        (M/Z)M.sup.+                                                                         NMR δ (CDCl.sub.3)                 __________________________________________________________________________                                           ppm                                      18 H                                                                                  ##STR24##                                                                              2  3  pale yellow crystals                                                                 120-125                                                                             387   1.07-2.20(2H, m), 2.20-2.84(10H,                                               m)2.68(3H, s), 3.04(2H, t),                                                    4.25(1H, s)5.20-5.77(1H, b),                                                   6.98-7.61(10H, m)                        19 H                                                                                  ##STR25##                                                                              2  5  pale yellow crystals                                                                 128-133                                                                             415   1.10-2.10(6H, m), 2.10-2.66(10H,                                               m)2.69-3.24(5H, m), 4.23(1H,                                                   s)4.30-4.70(1H, b), 7.10-7.60(10H,                                             m)                                       20 H                                                                                  ##STR26##                                                                              2  6  pale yellow crystals                                                                 190-192                                                                             429   1.20-2.05(8H, m), 2.15-2.61(10H,                                               m)2.69-3.20(5H, m), 4.22(1H,                                                   s)4.40-4.70(1H, b), 7.10-7.70(10H,                                             m)                                       21 4-Cl                                                                               ##STR27##                                                                              2  6  pale orange crystals                                                                 169-174                                                                             463   1.11-2.04(8H, m), 2.08-2.62(10H,                                               m)2.63-3.13(5H, m), 4.16(1H,                                                   s)4.47(1H, b), 6.98-7.46(9H, m)          22 4-F                                                                                ##STR28##                                                                              2  2  colorless crystals                                                                   165-170                                                                             392   1.85-3.37(15H, m), 4.43(1H,                                                    s)4.82-5.35(1H, b), 6.74- 8.80(8H,                                             m)                                       23 4-F                                                                                ##STR29##                                                                              2  3  pale yellow crystals                                                                 145-150                                                                             406   1.62-2.20(2H, m), 2.28-2.64(10H,                                               m)2.71(3H, s), 3.04(2H, t),                                                    4.39(1H, s)5.12-5.72(1H, b),                                                   6.74-8.52(8H, m)                         24 4-F                                                                                ##STR30##                                                                              2  4  yellow crystals                                                                      135-140                                                                             420   1.12-2.04(4H, m), 2.17-2.63(10H,                                               m), 2.79(3H, s), 2.88- 3.41(2H, m),                                            4.45(1H, s), 4.52-5.07(1H, b),                                                 6.77-8.67(8H, m)                         25 4-F                                                                                ##STR31##                                                                              2  5  pale yellow crystals                                                                 140-145                                                                             434   1.12-2.10(6H, m), 2.10-2.65(10H,                                               m), 2.78(3H, s), 2.78- 3.28(2H, m),                                            4.43(1H, s), 4.50-4.90(1H, b),                                                 6.68-8.63(8H, m)                         26 4-F                                                                                ##STR32##                                                                              2  6  yellow crystals                                                                      105-110                                                                             448   1.10-2.09(8H, m), 2.10-2.64(10H,                                               m), 2.76(3H, s), 2.65- 3.19(2H, m),                                            4.40(1H, s), 4.49(1H, b),                                                      6.76-8.55(8H, m)                         27 4-F                                                                                ##STR33##                                                                              2  7  yellow crystals                                                                      135-140                                                                             462   1.04-2.07(10H, m)2.07-2.68(10H, m),                                            2.82(3H, s), 2.70- 3.20(2H, m),                                                4.42(1H, s), 4.28-4.85(1H, b),                                                 6.70-8.62(8H, m)                         28 4-F                                                                                ##STR34##                                                                              2  8  yellow crystals                                                                      122-127                                                                             476   1.07-2.13(12H, m)2.13-2.67(10H,                                                m)2.67-3.27(5H, m), 4.40-4.77(1H,                                              b)4.45(1H, s), 6.77-8.62(8H,             __________________________________________________________________________                                           m)                                  

EXAMPLES 29 TO 35

Compounds of Table 7 below are prepared from various starting materials according to the same manner as described in Example 1 except using ethylamine instead of ammonia.

                                      TABLE 7                                      __________________________________________________________________________      ##STR35##                                                                     Ex.                        m p. MS                                             No.                                                                               R.sub.1                                                                           R.sub.2  a  n  aspect                                                                               (°C.)                                                                        (M/Z)M.sup.+                                                                         NMR δ (CDCl.sub.3)                 __________________________________________________________________________                                           ppm                                      29 4-Cl                                                                               ##STR36##                                                                              2  6  pale brown crystals                                                                  185-190                                                                             477   1.19(3H, t)1.16-2.06(8H,                                                       m)2.09-2.73(10H, m)2.77-3.18 (2H,                                              m)3.07(2H, q)4.17(1H, s)4.22(1H,                                               b), 7.04-7.45(9H, m)                     30 4-F                                                                                ##STR37##                                                                              2  3  yellow crystals                                                                      129-134                                                                             420   1.20(3H, t)1.67-2.27(2H,                                                       m)2.27-2.84(10H, m), 2.84-3.47 (4H,                                            m), 4.47(1H, s)4.49-5.54(1H, b),                                               6.79-8.77(8H, m)                         31 4-F                                                                                ##STR38##                                                                              2  5  pale yellow crystals                                                                 115-120                                                                             448   1.21(3H, t)1.07-2.19(6H,                                                       m)2.20-2.80(10H, m), 2.80- 3.39(4H,                                            m), 4.45(1H, s)4.20-4.75(1H, b),                                               6.77-8.60(8H, m)                         32 4-F                                                                                ##STR39##                                                                              2  6  yellowish red crystals                                                               128-133                                                                             462   1.05-2.00(8H, b)1.20(3H,                                                       t)2.00-2.75(10H, m), 2.80- 3.43(4H,                                            m), 4.47(1H, s)4.15-4.55(1H, b),                                               6.80-8.68(8H, m)                         33 4-F                                                                                ##STR40##                                                                              2  7  yellow crystals                                                                      88-92                                                                               476   1.02-2.07(10H, b)1.18(3H,                                                      t)2.07-2.71(10H, m)2.71-3.82 (4H,                                              m), 4.39(1H, s)4.50-4.94(1H, b),                                               6.78-8.52(8H, m)                         34 4-F                                                                                ##STR41##                                                                              2  8  pale brown crystals                                                                  153-159                                                                             490   1.13-2.07(12H, b)1.21(3H,                                                      t)2.50-3.32(14H, m), 4.49(1H,                                                  s)4.70(1H, b), 6.79-8.51(8H, m)          35 4-F                                                                                ##STR42##                                                                              2  10 brown crystals                                                                       131-136                                                                             518   1.28-2.10(19H, m)2.10-2.79(10H, m),                                            2.79-3.40(4H, m), 4.22-4.65(1H,                                                b)4.41(1H, s), 6.70-8.65(8H,             __________________________________________________________________________                                           m)                                  

EXAMPLES 36 TO 42

Compounds of Table 8 below are prepared from various starting materials according to the same manner as described in Example 1 except using propylamine instead of ammonia.

                                      TABLE 8                                      __________________________________________________________________________      ##STR43##                                                                     Ex.                        m p. MS                                             No.                                                                               R.sub.1                                                                           R.sub.2  a  n  aspect                                                                               (°C.)                                                                        (M/Z)M.sup.+                                                                         NMR δ (CDCl.sub.3)                 __________________________________________________________________________                                           ppm                                      36 4-Cl                                                                               ##STR44##                                                                              2  6  colorless crystals                                                                    99-103                                                                             491   0.94(3H, t)1.27-2.20(10H,                                                      m)2.24-2.79(10H, m)2.74-3.17 (2H,                                              m), 3.09(2H, t)4.18(1H, s)4.38(1H,                                             b), 7.00-7.53(9H, m)                     37 4-F                                                                                ##STR45##                                                                              2  3  pale yellow crystals                                                                 130-135                                                                             434   0.92(3H, t)1.15-2.25(4H, m),                                                   2.24-2.75(10H, m)2.75-3.30 (4H, m),                                            4.42(1H, s)4.88-5.32(1H, b),                                                   6.82-8.64(8H, m)                         38 4-F                                                                                ##STR46##                                                                              2  5  pale yellow crystals                                                                 114-119                                                                             462   0.90(3H, t)1.10-2.15(8H, m),                                                   2.15-2.75(10H, m)2.75-3.40 (4H, m),                                            4.42(1H, s)4.55-4.95(1H, b),                                                   6.70-8.65(8H, m)                         39 4-F                                                                                ##STR47##                                                                              2  6  yellow crystals                                                                      122-126                                                                             476   0.94(3H, t)1.19-2.12(10H, m),                                                  2.15-2.75(10H, m)2.76- 3.39(4H,                                                m)4.43(2H, b)6.70-8.53(8H, m)            40 4-F                                                                                ##STR48##                                                                              2  7  brown crystals                                                                       112-117                                                                             490   0.91(3H, t)1.10-2.08(12H, m),                                                  2.18-2.70(10H, m)2.73- 3.53(4H,                                                m)4.36(1H, s)4.52-5.01(1H, b),                                                 6.69-8.34(8H, m)                         41 4-F                                                                                ##STR49##                                                                              2  8  yellow crystals                                                                      118-122                                                                             504   0.97(3H, t)1.16-2.12(14H, m),                                                  2.12-2.72(10H, m)2.73- 3.48(4H,                                                m)4.42(1H, s)4.00-4.68(1H, b),                                                 6.48-8.54(8H, m)                         42 4-F                                                                                ##STR50##                                                                              2  10 brown crystals                                                                       111-115                                                                             532   0.80-2.08(21H, m), 2.14-2.77(10H,                                              m), 2.79-3.48(4H, m), 4.44(1H, s),                                             4.56(1H, b), 6.86-8.52(8H,               __________________________________________________________________________                                           m)                                  

EXAMPLES 43 TO 49

Compounds of Table 9 below are prepared from various starting materials according to the same manner as described in Example 1 except using isopropylamine instead of ammonia.

                                      TABLE 9                                      __________________________________________________________________________      ##STR51##                                                                     Ex.                    m.p. MS (M/                                             No.                                                                               R.sub.1                                                                           R.sub.2                                                                               a n  aspect                                                                              (°C.)                                                                        Z)M.sup.+                                                                           NMR δ(CDCl.sub.3)                       __________________________________________________________________________                                      ppm                                           43 4-Cl                                                                               ##STR52##                                                                            2 6  pale yellow crystals                                                                105-110                                                                             491  1.20(6H, d), 1.12-2.03(8H, m), 2.08-                                           2.67(10H, m), 2.77-3.11(2H, m), 3.59(1H,                                       ), 4.21(1H, s), 6.97-7.40(9H, m)              44 4-F                                                                                ##STR53##                                                                            2 3  pale yellow crystals                                                                137-142                                                                             434  1.21(6H, d)1.66-2.26(2H, m) 2.26-                                              2.76(10H, m)3.10(2H, t), 3.66(1H, q)4.46                                       1H, s)4.60-4.96(1H, b)6.82-8.66(8H, m;        45 "  "      2 5  yellow                                                                              119-124                                                                             462  1.11-2.13(12H, m), 2.15-2.76(10H, m)                            crystals       2.88-3.25(2H, m), 3.74(1H, s)4.17(1H,                                          b)4.97(1H, s), 6.86-8.63(8H, m)               46 "  "      2 6  yellow                                                                              127-132                                                                             476  1.22(6H, d)1.06-2.11(8H, m)2.17-2.78                            crystals       (10H, m)2.79-3.19(2H, m)3.67(1H, s)4.19                                        (1H, b)4.43(1H, s))6.67-8.53(8H, m            47 "  "      2 7  yellow                                                                              89-94                                                                               490  1.07-2.10(10H, m), 1.22(6H, d)2.10-                             crystals       2.70(10H, m)3.57(1H, s)4.16(1H, b)4.43                                         (1H, s), 6.77-8.51(8H, m)                     48 "  "      2 8  yellow                                                                              128-133                                                                             504  1.18-2.05(18H, m), 2.12-2.71(10H, m)                            crystals       2.83-3.18(2H, m)3.68(1H, q)4.19(1H, b),                                        4.42(1H, s), 6.80-8.53(8H, m)                 49 "  "      2 10 pale 122-127                                                                             532  0.88-2.09(22H, m), 2.11-2.80(10H, m)                            yellow         2.83-3.23(2H, m)3.56(1H, q)4.09(1H, b),                                        4.42(1H, s), 6.70-8.52(8H,                    __________________________________________________________________________                                      m)                                       

EXAMPLES 50 TO 53

Compounds of Table 10 below are prepared from various starting materials according to the same manner as described in Example 1 except using tert-butylamine instead of ammonia.

                                      TABLE 10                                     __________________________________________________________________________      ##STR54##                                                                     Ex.                        m p. MS                                             No.                                                                               R.sub.1                                                                           R.sub.2  a  n  aspect                                                                               (°C.)                                                                        (M/Z)M.sup.+                                                                         NMR δ (CDCl.sub.3)                 __________________________________________________________________________                                           ppm                                      50 4-Cl                                                                               ##STR55##                                                                              2  6  pale yellow crystals                                                                 128-132                                                                             505   1.04-2.26(17H, m), 2.43-3.53(12H,                                              m)4.34(1H, s), 6.23 (1H.                                                       s)7.05-7.50(9H, m)                       51 4-F                                                                                ##STR56##                                                                              2  6  brown crystals                                                                       146-149                                                                             490   1.07-2.16(17H, m), 2.17-2.76(8H,                                               m)2.80-3.26(4H, b), 4.35(1H,                                                   s)4.42(1H, s), 6.66-8.57(8H, m)          52 4-F                                                                                ##STR57##                                                                              2  8  yellow crystals                                                                      107-111                                                                             518   1.11-2.14(12H, m), 1.37(9H, s),                                                2.15-2.69(8H, m), 2.70- 3.24(4H,                                               m), 4.23(1H, b), 4.43(1H, s),                                                  6.79-8.63(8H, m)                         53 4-F                                                                                ##STR58##                                                                              2  10 pale yellow crystals                                                                 119-123                                                                             546   1.06-2.21(25H, m), 2.43-3.63(12H,                                              m)4.52(1H, s), 6.69- 8.69(8H,            __________________________________________________________________________                                           m)                                  

EXAMPLES 54 TO 58

Compounds of Table 11 below are prepared from various starting materials according to the same manner as described in Example 1 except using cyclopropylamine instead of ammonia.

                                      TABLE 11                                     __________________________________________________________________________      ##STR59##                                                                     Ex.                        m p. MS                                             No.                                                                               R.sub.1                                                                           R.sub.2  a  n  aspect                                                                               (°C.)                                                                        (M/Z)M.sup.+                                                                         NMR δ (CDCl.sub.3)                 __________________________________________________________________________                                           ppm                                      54 4-Cl                                                                               ##STR60##                                                                              2  6  pale yellow crystals                                                                 140-144                                                                             490   0.68(4H, d), 1.15-2.13(8H, m),                                                 2.27-3.33(13H, m)4.26 (1H,                                                     s)5.70(1H, b), 7.07-7.46(9H, m)          55 4-F                                                                                ##STR61##                                                                              2  4  pale brown crystals                                                                  125-129                                                                             446   0.66(4H, d), 1.38-2.13(4H, m),                                                 2.15-2.75(11H, m), 2.83- 3.24(2H,                                              m), 4.32(1H, s), 4.98(1H, b),                                                  6.66-8.32(8H, m)                         56 4-F                                                                                ##STR62##                                                                              2  6  yellow crystals                                                                      107-112                                                                             474   0.67(4H, d), 1.20-2.08(8H, m),                                                 2.09-2.78(11H, m), 2.86- 3.28(2H,                                              m), 4.34(1H, s), 4.91(1H, b),                                                  6.73-8.46(8H, m)                         57 4-F                                                                                ##STR63##                                                                              2  8  yellow crystals                                                                      116-121                                                                             502   0.67(4H, d), 1.03-2.08(12H, m),                                                2.10-2.80(11H, m), 2.82- 3.27(2H,                                              m), 4.36(1H, s), 4.93(1H, b),                                                  6.21-8.41(8H, m)                         58 4-F                                                                                ##STR64##                                                                              2  10 pale brown crystals                                                                  112-117                                                                             530   0.69(4H, d), 1.03-2.05(16H, m),                                                2.09-2.77(11H, m), 2.87- 3.27(2H,                                              m), 4.37(1H, s), 4.95(1H, b),                                                  6.73-8.53(8H, m)                         __________________________________________________________________________

EXAMPLES 59 TO 63

Compounds of Table 12 below are prepared from various starting materials according to the same manner as described in Example 1 except using cyclopentylamine instead of ammonia.

                                      TABLE 12                                     __________________________________________________________________________      ##STR65##                                                                     Ex.                        m p. MS                                             No.                                                                               R.sub.1                                                                           R.sub.2  a  n  aspect                                                                               (°C.)                                                                        (M/Z)M.sup.+                                                                         NMR δ (CDCl.sub.3)                 __________________________________________________________________________                                           ppm                                      59 4-Cl                                                                               ##STR66##                                                                              2  6  pale yellow crystals                                                                 86-90                                                                               517   1.13-2.72(26H, m), 3.02(2H,                                                    m)3.39-3.98(1H, m), 4.21 (1H,                                                  s)4.30(1H, b), 7.11-7.57(9H, m)          60 4-F                                                                                ##STR67##                                                                              2  4  brown crystals                                                                       128-132                                                                             474   1.30-2.13(12H, m), 2.17-3.31(12H,                                              m)3.32-3.97(1H, m), 4.32(2H, b),                                               6.64-8.32(8H, m)                         61 4-F                                                                                ##STR68##                                                                              2  6  pale brown crystals                                                                  123-128                                                                             502   1.22-2.80(26H, m), 2.81-3.28(2H,                                               m)3.52-4.05(1H, m), 4.46(2H, b),                                               6.79-8.51(8H, m)                         62 4-F                                                                                ##STR69##                                                                              2  8  brown crystals                                                                       128-132                                                                             530   0.93-2.75(30H, m), 2.76-3.16(2H,                                               m)3.46-4.03(1H, m), 4.38(2H, b),                                               6.79-8.42(8H, m)                         63 4-F                                                                                ##STR70##                                                                              2  10 pale brown crystals                                                                  119-123                                                                             558   1.01-2.77(34H, m), 2.78-3.18(2H,                                               m)3.41-4.02(1H, m), 4.22(1H,                                                   b)4.37(1H, s), 6.69-8.55(8H,             __________________________________________________________________________                                           m)                                  

EXAMPLES 64 TO 86

Compounds of Table 13 below are prepared from various starting materials according to the same manner as described in Example 1 except using dimethylamine instead of ammonia.

                                      TABLE 13                                     __________________________________________________________________________      ##STR71##                                                                     Ex. No.                                                                             R.sub.1                                                                            R.sub.2   a n  aspect                                                                               m p. (°C.)                                                                    MS (M/Z) M.sup.+                                                                       NMR δ (CDCl.sub.3)           __________________________________________________________________________                                                 ppm                                64   4-Cl                                                                                ##STR72##                                                                               2  6 pale brown crystals                                                                   93-96                                                                               477     1.12-2.08(8H, m),                                                              2.22-2.63(10H,                                                                 m) 2.72-3.12(2H, m), 2.83(6H,                                                  s), 4.16 (1H, s),                                                              6.98-7.46(9H, m)                   65   4-F                                                                                 ##STR73##                                                                               2  6 pale brown crystals                                                                  131-136                                                                              479     1.18-2.06(8H, m),                                                              2.08-2.63(10H,                                                                 m) 2.72-3.12(2H, m), 2.84(6H,                                                  s), 4.21 (1H, s),                                                              6.71-7.57(8H, m)                   66   4-Cl                                                                                ##STR74##                                                                               2  6 pale brown crystals                                                                  103-107                                                                              478     1.14-2.12(8H, m),                                                              2.16-2.69(10H,                                                                 m) 2.70-3.14(2H, m), 2.85(6H,                                                  s), 4.21 (1H, s),                                                              7.19-8.47(8H, m)                   67   H                                                                                   ##STR75##                                                                               2  6 yellow crystals                                                                      105-110                                                                              444     1.19-2.07(8H, m),                                                              2.08-2.68(10H,                                                                 m) 2.70-3.07(2H, m), 2.84(6H,                                                  s), 4.41 (1H, s),                                                              6.87-8.45(9H, m)                   68   4-F                                                                                 ##STR76##                                                                               2  6 pale brown crystals                                                                  119-123                                                                              461     1.15-2.08(8H, m),                                                              2.09-2.68(10H,                                                                 m) 2.69-3.04(2H, m), 2.82(6H,                                                  s), 4.18 (1H, s),                                                              6.73-7.55(9H, m)                   69   2-F "         2  8 pale brown                                                                            93-96                                                                               489     1.03-2.03(12H, m),                                                             2.04-2.57(10H, m)                                          crystals            2.60-2.95(2H, m), 3.03(6H,                                                     s), 4.49                                                                       (1H, s), 6.50-7.72(9H, m)          70   4-CH.sub.3                                                                         "         2  6 colorless                                                                            143-147                                                                              457     1.16-2.12(8H, m), 2.26(3H,                                                     s)                                                         crystals            2.36-3.10(12H, m), 2.83(6H,                                                    s), 4.21                                                                       (1H, s), 6.90-7.50(9H, m)          71   4-F                                                                                 ##STR77##                                                                               2  6 pale brown crystals                                                                  129-134                                                                              462     1.17-2.10(8H, m),                                                              2.14-2.71(10H,                                                                 m) 2.72-3.12(2H, m), 2.84(6H,                                                  s), 4.29 (1H, s),                                                              6.69-8.72(8H, m)                   72   4-CF.sub.3                                                                          ##STR78##                                                                               2  6 pale brown crystals                                                                  107-112                                                                              511     1.10-2.11(8H, m),                                                              2.13-2.67(10H,                                                                 m) 2.71-3.13(2H, m), 2.85(6H,                                                  s), 4.27 (1H, s),                                                              7.09-7.61(9H, m)                   73   3-CF.sub.3                                                                         "         2  8 pale brown                                                                            98-102                                                                              539     1.09-2.08(12H, m),                                                             2.14-2.63(10H, m)                                          crystals            2.68-3.10(2H, m), 2.80(6H,                                                     s), 4.21                                                                       (1H, s), 6.94-7.61(9H, m)          74   4-MeO                                                                              "         2  6 brown 124-129                                                                              473     1.10-2.09(8H, m),                                                              2.11-2.66(10H, m)                                          crystals            2.68-3.08(2H, m), 2.83(6H,                                                     s), 3.71                                                                       (3H, s), 4.16(1H, s),                                                          6.61-7.51(9H, m)                   75   4-NO.sub.2                                                                         "         2  6 brown 112-117                                                                              488     1.17-2.10(8H, m),                                                              2.14-2.71(10H, m)                                          crystals            2.72-3.12(2H, m), 2.84(6H,                                                     s), 4.29                                                                       (1H, s), 7.08-8.27(9H, m)          76   H                                                                                   ##STR79##                                                                               2  6 colorless crystals                                                                   157-161                                                                              511     1.14-2.07(8H, m),                                                              2.08-2.61(10H,                                                                 m) 2.69-3.08(2H, m), 2.81(6H,                                                  s), 4.14 (1H, s),                                                              7.01-7.47(8H, m)                   77   4-F                                                                                 ##STR80##                                                                               3  6 brown crystals                                                                       106-110                                                                              476     1.08-2.31(10H, m),                                                             2.40-3.20(18H, m) 4.76(1H,                                                     s), 6.71-8.59(8H, m)               78   4-Cl                                                                                ##STR81##                                                                               2  8 pale yellow crystals                                                                  99-104                                                                              539     1.14-2.06(12H, m),                                                             2.15-2.70(10H,                                                                 m) 2.73-3.12(2H, m), 2.88(6H,                                                  s) 4.21(1H, s), 7.12-7.54(8H,                                                  m)                                 79   4-F                                                                                 ##STR82##                                                                               2  2 pale yellow crystals                                                                 110-114                                                                              406     2.23-2.81(10H, m),                                                             2.82-3.39(2H, m) 2.89(6H, s),                                                  4.97(1H, s) 6.89-8.60(8H, m)       80   "   "         2  3 pale brown                                                                           103-108                                                                              420     1.79-2.28(2H, m),                                                              2.30-2.73(10H, m)                                          crystals            2.83-3.20(2H, m), 2.88(6H,                                                     s), 4.44                                                                       (1H, s), 6.81-8.55(8H, m)          81   "   "         2  5 yellow                                                                               112-117                                                                              448     1.19-2.18(6H, m),                                                              2.19-2.75(10H, m)                                          crystals            2.78-3.16(2H, m), 2.91(6H,                                                     s), 4.49                                                                       (1H, s), 6.77-8.58(8H, m)          82   "   "         2  6 yellow                                                                               142-147                                                                              462     1.10-2.07(8H, m),                                                              2.12-2.73(10H, m)                                          crystals            2.74-3.09(2H, m), 2.88(6H,                                                     s), 4.47                                                                       (1H, s), 6.79-8.59(8H, m)          83   "   "         2  7 brown 121-126                                                                              476     1.10-2.02(10H, m),                                                             2.08-2.62(10H, m)                                          crystals            2.69-3.11(2H, m), 2.79(6H,                                                     s), 4.32                                                                       (1H, s), 6.61-8.31(8H, m)          84   "                                                                                   ##STR83##                                                                               2  8 yellow crystals                                                                      127-131                                                                              490     1.13-2.01(12H, m),                                                             2.04-2.63(10H,                                                                 m) 2.24-3.23(2H, m), 2.84(6H,                                                  s), 4.40 (1H, s),                                                              6.80-8.53(8H, m)                   85   4-F "         2 10 brown 118-122                                                                              518     1.15-2.20(16H, m),                                                             2.20-2.72(10H, m)                                          crystals            2.72-3.10(2H, m), 2.89(6H,                                                     s), 4.45                                                                       (1H, s), 6.70-8.53(8H, m)          86   "   "         2 12 yellow                                                                               110-115                                                                              546     1.14-2.21(20H, m),                                                             2.30-2.79(8H, m)                                           crystals            2.80-3.20(2H, m), 2.91(6H,                                                     s), 3.41-3.77                                                                  (2H, m) 4.49(1H, m),                                                           6.83-8.59(8H,                      __________________________________________________________________________                                                 m)                            

EXAMPLES 87 TO 93

Compounds of Table 14 below are prepared from various starting materials according to the same manner as described in Example 1 except using aniline instead of ammonia.

                                      TABLE 14                                     __________________________________________________________________________      ##STR84##                                                                     Ex. No.                                                                             R.sub.1                                                                            R.sub.2 a  n  aspect m p. (°C.)                                                                    MS (M/Z) M.sup.+                                                                       NMR δ (CDCl.sub.3)           __________________________________________________________________________                                                 ppm                                87   4-Cl                                                                                ##STR85##                                                                             2   6 pale yellow crystals                                                                   91-95                                                                               525     1.13-2.08(8H, m),                                                              2.09-2.65(10H,                                                                 m) 2.88-3.27(2H, m), 4.13(1H,                                                  s), 4.95 (1H, b),                                                              6.98-7.50(14H, m)                  88   4-F                                                                                 ##STR86##                                                                             2   3 pale yellow crystals                                                                  106-110                                                                              468     1.72-2.18(2H, m),                                                              2.18-2.81(10H, m) 3.19(2H,                                                     t), 4.34(1H,                                                                   s) 6.44-8.54(13H, m)               89   "   "       2   5 colorless                                                                             138-142                                                                              496     1.16-2.09(6H, m),                                                              2.10-2.81(10H, m)                                         crystals             2.92-3.26(2H, m), 4.42(1H,                                                     s), 4.64                                                                       (1H, b), 6.75-8.53(13H, m)         90   "   "       2   6 pale brown                                                                            123-129                                                                              510     1.01-2.05(8H, m),                                                              2.06-2.70(10H, m)                                         crystals             3.07(2H, m), 4.40(1H, s),                                                      5.44(1H, b)                                                                    6.67-8.48(13H, m)                  91   "   "       2   7 pale brown                                                                            113-118                                                                              524     1.02-2.06(10H, m),                                                             2.07-2.69(10H, m)                                         crystals             2.89-3.26(2H, m), 4.22(1H,                                                     b)                                 92   "   "       2   8 pale brown                                                                            130-134                                                                              538     1.02-2.09(12H, m),                                                             2.11-2.66(10H, m)                                         crystals             2.83-3.26(2H, m), 4.39(1H,                                                     s)                                                                             4.97(1H, b) 6.42-8.43(13H,                                                     m)                                 93   "   "       2  10 brown  117-122                                                                              566     0.90-2.11(16H, m),                                                             2.13-2.71(10H, m)                                         crystals             2.91-3.25(2H, m), 4.39(1H,                                                     s)                                                                             5.28(1H, b) 6.72-8.43(13H,         __________________________________________________________________________                                                 m)                            

EXAMPLES 94 TO 97

Compounds of Table 15 below are prepared from various starting materials according to the same manner as described in Example 1 except using o-aminophenol instead of ammonia.

                                      TABLE 15                                     __________________________________________________________________________      ##STR87##                                                                     Ex. No.                                                                             R.sub.1                                                                            R.sub.2 a  n  aspect                                                                               m p. (°C.)                                                                     MS (M/Z) M.sup.+                                                                       NMR δ (CDCl.sub.3)           __________________________________________________________________________                                                 ppm                                94   4-Cl                                                                                ##STR88##                                                                             2  6  colorless crystals                                                                   106-110                                                                               541     1.07-2.05(8H, m),                                                              2.31-3.23(12H, m) 4.22(1H,                                                     s), 6.64-7.61(15H, m)              95   4-F                                                                                 ##STR89##                                                                             2  4  brown crystals                                                                       103-107                                                                               498     1.37-2.22(4H, m),                                                              2.35-3.26(12H, m) 4.46(1H,                                                     s), 6.35-8.67(14H, m)              96   "   "       2  6  yellow                                                                               128-133                                                                               526     0.90-2.20(8H, m),                                                              2.45-3.31(12H, m)                                         crystals             4.51(1H, s), 6.21(2H, b)                                                       6.58-8.61(12H, m)                  97   H                                                                                   ##STR90##                                                                             2  8  brown crystals                                                                       134-139                                                                               535     0.87-2.11(12H, m),                                                             2.12-3.32(12H, m) 4.14(1H,                                                     s), 6.16(2H,                                                                   b) 6.52-7.63(14H,                  __________________________________________________________________________                                                 m)                            

EXAMPLES 98 TO 100

Compounds of Table 16 below are prepared from various starting materials according to the same manner as described in Example 1 except using R₃ --NH₂ instead of ammonia.

                                      TABLE 16                                     __________________________________________________________________________      ##STR91##                                                                     Ex.          R.sub.3                 MS (M/                                    No.                                                                               R.sub.1                                                                           R.sub.2                                                                               a n (R.sub.4 = H)                                                                            aspect                                                                              (°C.)                                                                        Z)M.sup.+                                                                           NMR δ(CDCl.sub.3)              __________________________________________________________________________                                               ppm                                  98 4-Cl                                                                               ##STR92##                                                                            2 6                                                                                 ##STR93##                                                                               brown crystals                                                                      105-109                                                                             615  1.20-2.12(8H, m), 2.56-2.86                                                    (12H, m), 3.74(3H, s), 3.78(6H,                                                ), 4.26(1H, s) 6.95-7.48(12H,                                                  m)                                   99 H  "      2 6 "         pale 109-113                                                                             581  1.14-2.15(8H, m), 2.52-3.28                                     brown          (12H, m), 3.77(3H, s), 3.80                                     crystals       (6H, s), 4.29(1H, s),                                                          6.41-6.87                                                                      (1H, b), 6.69(2H, s)                                                           7.04-7.59(10H, m)                    100                                                                               4-Cl                                                                              "      2 6                                                                                 ##STR94##                                                                               pale brown crystals                                                                 231-234                                                                             653  1.15-2.32(26H, m), 2.62-3.38                                                   (12H, m), 4.32(1H, s), 5.10(1H,                                                ), 7.07-7.47(11H,                    __________________________________________________________________________                                               m)                              

EXAMPLE 101

Compound of Table 17 below is prepared from corresponding starting material according to the same manner as described in Example 1 except using β-aminoethyl alcohol instead of ammonia.

                                      TABLE 17                                     __________________________________________________________________________      ##STR95##                                                                     Ex. No.                                                                             R.sub.1                                                                            R.sub.2 a  n  aspect                                                                               m p. (°C.)                                                                     MS (M/Z) M.sup.+                                                                       NMR δ (CDCl.sub.3)           __________________________________________________________________________                                                 ppm                                101  4-Cl                                                                                ##STR96##                                                                             2  6  colorless crystals                                                                   125-130                                                                               494     1.14-2.06(8H, m),                                                              2.13-2.62(10H,                                                                 m) 2.76-3.42(5H, m),                                                           3.54-3.88(3H, m) 4.16(1H, s),                                                  7.04-7.54(9H,                      __________________________________________________________________________                                                 m)                            

EXAMPLE 102 (Method B)

Preparation of 3- 4- 4-fluorophenyl-(2-pyridyl)methyl!-1-piperazinyl!propylsulfonyl methylethylamine hydrochloride

3-Chloropropanesulfonyl chloride (2.54 g) is dissolved in methylene chloride and isopropylamine (1.90 g) is added dropwise under ice cooling. After stirring at room temperature for 2 hours, the solution is extracted with methylene chloride and water to give crude 3-chloropropanesulfonyl methylethylamine (2.54 g, 89%) as pale yellow liquid.

The above compound (2.54 g), 4-fluorophenyl-(2-pyridyl)methyl!piperazine (4.14 g) and triethylamine (1.54 g) are dissolved in toluene. After refluxing for 48 hours, water is added to the mixture and the toluene layer is separated and dried over anhydrous magnesium sulfate. The filtrate is concentrated under reduced pressure to give brown liquid. The liquid is treated by column chromatography silica gel, chloroform-methanol (20:1)! and the resulting purified material (4.49 g, 81%) is converted into hydrochloride by using hydrochloric acid-methanol solution and recrystallized from ethanol-diethyl ether to give the title compound as pale yellow crystals. mp.137°-142° C.

Mass Spectrum (MS): m/z:434(M⁺);

NMR Spectrum: δ(CDCl₃) ppm: 1.21 (6H, d), 1.66-2.26 (2H, m), 2.26-2.76 (10H, m), 3.10 (2H, t), 3.66 (1 H, q), 4.46 (1 H, s), 4.60-4.96 (1 H, b), 6.82-8.66 (8H, m).

EXAMPLE 103 (Method C)

Preparation of 6- 4- 4-fluorophenyl-(2-pyridyl)methyl!-1-piperazinyl!hexylsulfonyl dimethylamine, hydrochloride

6-(1-Piperazinyl)hexylsulfondimethylamine (1.5 g) and triethylamine (0.6 g) are added to a flask and dissolved in isopropanol (50 ml) and a solution of 4-fluorophenyl-(2-pyridyl)methyl! chloride (1.3 g) in isopropanol is added dropwise. After stirring at room temperature for 16 hours, the solution is refluxed for 2 hours. The reaction mixture is concentrated under reduced pressure and extracted with chloroform and water. The chloroform layer is separated and dried over anhydrous magnesium sulfate. The filtrate is concentrated under reduced pressure to give brown liquid. The liquid is treated by column chromatography silica gel, chloroform-methanol (20:1)! and the resulting purified material (0.6 g, 24%) is converted into hydrochloride by using hydrochloric acid-methanol solution and recrystallized from ethanol-diethyl ether to give the title compound as pale yellow crystals. mp.142°-147° C.

Mass Spectrum (MS): m/z:462(M⁺);

NMR Spectrum: δ(CDCl₃) ppm: 1.10-2.07 (8H, m), 2.12-2.73 (10H, m), 2.74-3.09 (2H, m), 2.88 (6H, s), 4.47 (1 H, s), 6.79-8.59 (8H, m).

EXAMPLES 104 AND 105

Compounds of Table 18 below are prepared from corresponding starting materials according to the same manner as described in Example 1.

                                      TABLE 18                                     __________________________________________________________________________      ##STR97##                                                                     Ex.                  m p. MS (M/                                               No.                                                                               R.sub.1                                                                           R.sub.2                                                                               a n aspect                                                                             (°C.)                                                                        Z)M.sup.+                                                                          NMR δ (CDCl.sub.3) ppm                     __________________________________________________________________________     104                                                                               4-Cl                                                                               ##STR98##                                                                            2 10                                                                               color- less crystals                                                               176-178                                                                             505 1.04-1.67(16H, m), 2.12-2.76(10H, m)                                           2.97-3.31(2H, m), 4.28(1H, s), 4.48-                                           5.00(2H, b), 7.20-7.64(9H, m)                    105                                                                               "  "      2 12                                                                               color-                                                                             156-161                                                                             533 1.08-2.04(20H, m), 2.13-2.63(10H, m)                              less         2.84-3.22(2H, m), 4.18(1H, s), 4.39-                              crystals     4.88(2H, b), 7.08-7.57(9H,                       __________________________________________________________________________                                   m)                                          

EXAMPLE 106

Compound of Table 19 below is prepared from corresponding starting material according to the same manner as described in Example 1 except using methylamine instead of ammonia.

                                      TABLE 19                                     __________________________________________________________________________      ##STR99##                                                                     Ex.                  m p. MS (M/                                               No.                                                                               R.sub.1                                                                           R.sub.2                                                                               a n aspect                                                                             (°C.)                                                                        Z)M.sup.+                                                                          NMR δ (CDCl.sub.3) ppm                     __________________________________________________________________________     106                                                                               4-Cl                                                                               ##STR100##                                                                           2 5 pale yellow crystals                                                               105-109                                                                             449 1.20-2.11(6H, m), 2.18-2.66(10H, m)                                            2.75(3H, s), 2.70-3.22(2H, m), 4.20 (1H,                                       s), 4.34-4.72(1H, b), 7.02-7.56 (9H,             __________________________________________________________________________                                   m)                                          

EXAMPLES 107 AND 108

Compounds of Table 20 below are prepared from corresponding starting materials according to the same manner as described in Example 1 except using ethylamine instead of ammonia.

                                      TABLE 20                                     __________________________________________________________________________      ##STR101##                                                                    Ex.                  m p. MS (M/                                               No.                                                                               R.sub.1                                                                           R.sub.2                                                                               a n aspect                                                                             (°C.)                                                                        Z)M.sup.+                                                                          NMR δ (CDCl.sub.3) ppm                     __________________________________________________________________________     107                                                                               4-Cl                                                                               ##STR102##                                                                           2 7 pale yellow crystals                                                               91-95                                                                               491 1.17(3H, t), 1.01-2.05(10H, m), 2.09-                                          2.76(10H, m), 2.77-3.45(4H, m), 4.19 (1H,                                      s), 4.39(1H, b), 7.06-7.64(9H, m)                108                                                                               "  "      2 8 pale                                                                               89-93                                                                               505 1.20(3H, t), 0.99-2.16(12H, m) 2.25-                              yellow       2.81(10H, m), 2.82-3.43(4H, m), 4.22                              crystals     (1H s), 4.36-4.87(1H, b), 7.07-7.58                                            (9H, m)                                          __________________________________________________________________________

EXAMPLE 109

Compound of Table 21 below is prepared from corresponding starling material according to the same manner as described in Example 1 except using propylamine instead of ammonia.

                                      TABLE 21                                     __________________________________________________________________________      ##STR103##                                                                    Ex.                  m p. MS (M/                                               No.                                                                               R.sub.1                                                                           R.sub.2                                                                               a n aspect                                                                             (°C.)                                                                        Z)M.sup.+                                                                          NMR δ (CDCl.sub.3) ppm                     __________________________________________________________________________     109                                                                               4-Cl                                                                               ##STR104##                                                                           2 10                                                                               color- less crystals                                                               134-136                                                                             547 0.90(3H, t), 1.09-1.99(18H, m), 2.10-                                          2.64(10H, m), 2.73-3.28(4H, m), 4.18 (1H,                                      s), 4.09-4.57(1H, b), 6.99-7.54 (9H,             __________________________________________________________________________                                   m)                                          

EXAMPLES 110 AND 111

Compounds of Table 22 below are prepared from corresponding starting materials according to the same manner as described in Example 1 except using isopropylamine instead of ammonia.

                                      TABLE 22                                     __________________________________________________________________________      ##STR105##                                                                    Ex.                   m.p. MS (M/                                              No.                                                                               R.sub.1                                                                           R.sub.2                                                                               a n aspect                                                                              (°C.)                                                                        Z)M.sup.+                                                                           NMR δ(CDCl.sub.3)                        __________________________________________________________________________                                     ppm                                            110                                                                               4-Cl                                                                               ##STR106##                                                                           2 5 pale yellow crystals                                                                101-105                                                                             477  1.19(6H, d), 1.04-2.11(6H, m), 2.17-                                           2.75(10H, m), 2.76-3.14(2H, m), 3.63 (1H,                                      q), 4.16(1H, s), 4.25(1H, s), 7.01-                                            7.54(9H, m)                                    111                                                                               "  "      2 8 pale 85-89                                                                               519  1.25(6H, d), 1.15-2.20(12H, m), 2.34-                           yellow         3.22(12H, m)3.38-3.91(1H, m), 4.27                              crystals       (1H, s), 4.41(1H, d), 7.06-7.50(9H,            __________________________________________________________________________                                     m)                                        

EXAMPLES 112 TO 126

Compounds of Table 23 below are prepared from corresponding starting materials according to the same manner as described in Example 1 except using cyclopropylamine instead of ammonia.

                                      TABLE 23                                     __________________________________________________________________________      ##STR107##                                                                    Ex.                    m p. MS (M/                                             No.                                                                               R.sub.1                                                                           R.sub.2  a n aspect                                                                             (°C.)                                                                        Z)M.sup.+                                                                          NMR δ (CDCl.sub.3)                       __________________________________________________________________________                                     ppm                                            112                                                                               4-Cl                                                                               ##STR108##                                                                             2 3 pale brown crystals                                                                137-142                                                                             447 0.65(4H, d), 1.58-2.78(13H, m), 3.15 (2H,                                      t), 4.21(1H, s), 5.48-6.00(1H, b)                                              6.98-7.52(9H, m)                               113                                                                               "  "        2 4 pale                                                                               136-141                                                                             461 0.63(4H, d), 1.21-1.99(4H, m), 2.08-                              brown        2.71(11H, m), 3.05(2H, t), 4.18(1H, s)                            crystals     5.01(1H, b), 6.99-7.50(9H, m)                  114                                                                               "  "        2 5 pale                                                                               125-130                                                                             475 0.66(4H, d), 1.13-2.02(6H, m), 2.14-                              brown        2.73(11H, m), 2.73-3.25(2H, m), 4.23                              crystals     (1H, s), 5.12(1H, b), 7.03-7.57(9H, m)         115                                                                               "  "        2 7 pale                                                                               122-127                                                                             503 0.69(4H, d), 1.08-1.98(10H, m), 2.11-                             brown        2.77(11H, m), 2.86-3.27(2H, m), 4.22                              crystals     (1H, s), 4.86(1H, b), 6.98-7.56(9H, m)         116                                                                               "  "        2 8 pale                                                                               117-123                                                                             517 0.67(4H, d), 1.09-2.76(23H, m), 2.88-                             brown        3.27(2H, m), 4.22(1H, s), 5.05-5.41                               crystals     (1H, b), 7.08-7.57(9H, m)                      117                                                                               "  "        2 9 pale                                                                               109-115                                                                             531 0.54(4H, d), 0.89-1.99(14H, m), 2.00-                             yellow       2.59(11H, m), 2.72-3.16(2H, m), 4.11                              crystals     (1H, s), 4.75(1H, b), 6.99-7.48(9H, m)         118                                                                               "  "        2 10                                                                               pale                                                                               105-109                                                                             545 0.69(4H, d), 0.97-1.96(16H, m), 2.02-                             yellow       2.73(11H, m), 2.83-3.28(2H, m), 4.20                              crystals     (1H, s), 4.91(1H, b), 7.01-7.54(9H, m)         119                                                                               "  "        2 12                                                                               yellow                                                                             104-109                                                                             573 0.66(4H, d), 0.93-1.97(20H, m), 1.99-                             crystals     2.69(11H, m), 2.78-3.20(2H, m), 4.10                                           (1H, s), 4.71(1H, b), 6.87-7.37(9H, m)         120                                                                               3-Cl                                                                              "        2 6 color-                                                                             169-176                                                                             489 0.65(4H, d), 1.11-1.99(8H, m), 2.08-                              less         2.73(11H, m), 4.19(1H, s), 4.62(1H, s)                            crystlas     7.02-7.51(9H, m)                               121                                                                               2-Cl                                                                               ##STR109##                                                                             2 6 color- less crystals                                                               123-129                                                                             489 0.65(4H, d), 1.11-1.93(8H, m), 2.07-                                           2.69(11H, m), 2.84-3.16(2H, m), 4.68-                                          5.02(1H, b), 4.77(1H, s), 6.89-7.84 (9H,                                       m)                                             122                                                                               4-Cl                                                                               ##STR110##                                                                             2 6 yellow crystals                                                                    106-111                                                                             490 0.65(4H, d), 1.02-2.68(18H, m), 2.82-                                          3.26(3H, m), 4.44(1H, s), 5.52-5.87 (1H,                                       b), 6.85-8.63(8H, m)                           123                                                                               H  "        2 6 yellow                                                                             69-81                                                                               456 0.66(4H, d), 1.12-2.04(8H, m), 2.09-                              crystals     2.72(11H, m), 3.15(2H, t), 4.42(1H, s)                                         4.61(H, s), 6.85-8.56(9H, m)                   124                                                                               4-F                                                                                ##STR111##                                                                             2 6 plae yellow crystals                                                               115-119                                                                             473 0.68(4H, d), 1.22-1.98(8H, m), 2.26-                                           2.61(11H, m), 3.01-3.12(2H, m), 4.21 (1H,                                      s), 4.62(1H, b), 6.88-7.42(9H, m)              125                                                                               "                                                                                  ##STR112##                                                                             2 6 color- less crystals                                                               184-187                                                                             491 0.68(4H, d), 1.18-3.33(21H, m), 4.36 (1H,                                      s), 6.30(1H, b), 6.69-7.59(8H, m)              126                                                                               H                                                                                  ##STR113##                                                                             2 6 pale brown crystals                                                                128-133                                                                             455 0.66(4H, d), 1.12-2.15(8H, m), 2.24-                                           3.34(13H, m), 4.32(1H, s), 6.60(1H, b)                                         7.02-7.58(10H, m)                              __________________________________________________________________________

EXAMPLES 127 TO 134

Compounds of Table 24 below are prepared from corresponding starting materials according to the same manner as described in Example 1 except using cyclobutylamine instead of ammonia.

                                      TABLE 24                                     __________________________________________________________________________      ##STR114##                                                                    Ex.                  m p. MS (M/                                               No.                                                                               R.sub.1                                                                           R.sub.2                                                                               a n aspect                                                                             (°C.)                                                                        Z)M.sup.+                                                                          NMR δ (CDCl.sub.3) ppm                     __________________________________________________________________________     127                                                                               4-Cl                                                                               ##STR115##                                                                           2 5 pale yellow crystals                                                               114-118                                                                             489 1.19-2.60(22H, m), 2.73-3.20(2H, m)                                            3.44-4.00(1H, m), 4.21(1H, s), 4.81 (1H,                                       d), 7.03-7.52(9H, m)                             128                                                                               "  "      2 6 pale                                                                               117-121                                                                             503 0.96-2.55(24H, m), 2.67-3.06(2H, m)                               yellow       3.55-4.07(1H, m), 4.15(1H, s), 4.75                               crystals     (1H, d), 6.96-7.48(9H, m)                        129                                                                               "  "      2 7 pale                                                                               118-124                                                                             517 0.96-2.60(26H, m), 2.69-3.10(2H, m)                               yellow       3.55-4.03(1H, m), 4.19(1H, s), 4.78                               crystals     (1H, d), 6.96-7.52(9H, m)                        130                                                                               "  "      2 8 color-                                                                             106-112                                                                             531 1.03-2.65(28H, m), 2.74-3.25(2H, m)                               less         3.68-4.08(1H, m), 4.22(1H, s), 4.75                               crystals     (1H, d), 7.06-7.55(9H, m)                        131                                                                               3-Cl                                                                              "      2 6 color-                                                                             129-135                                                                             503 1.10-2.67(24H, m), 2.77-3.16(2H, m)                               less         3.51-4.04(1H, m), 4.22(1H, s), 4.65                               crystals     (1H, d), 7.07-7.60(9H, m)                        132                                                                               2-Cl                                                                              "      2 6 pale                                                                               121-127                                                                             503 1.12-2.61(24H, m), 2.71-3.19(2H, m)                               yellow       3.53-4.00(1H, m), 4.80(1H, s), 5.11-                              crystals     5.58(1H, b), 6.91-7.93(9H, m)                    133                                                                               4-F                                                                                ##STR116##                                                                           2 6 yellow crystals                                                                     98-105                                                                             488 1.14-3.09(26H, m), 3.60-4.15(1H, m)                                            4.44(1H, s), 5.39(1H, d), 6.65-8.60 (8H,                                       m)                                               134                                                                               H                                                                                  ##STR117##                                                                           2 6 yellow crystals                                                                    123-127                                                                             469 1.20-2.62(24H, m), 2.72-3.13(2H, m)                                            3.54-3.99(1H, m), 4.21(1H, s), 5.07 (1H,                                       d), 6.93-7.52(10H, m)                            __________________________________________________________________________

EXAMPLES 135 TO 141

Compounds of Table 25 below are prepared from various starting materials according to the same manner as described in Example 1 except using cyclopentylamine instead of ammonia.

                                      TABLE 25                                     __________________________________________________________________________      ##STR118##                                                                    Ex.                  m p. MS (M/                                               No.                                                                               R.sub.1                                                                           R.sub.2                                                                               a n aspect                                                                             (°C.)                                                                        Z)M.sup.+                                                                          NMR δ (CDCl.sub.3) ppm                     __________________________________________________________________________     135                                                                               4-Cl                                                                               ##STR119##                                                                           2 4 yellow crystals                                                                    127-133                                                                             489 1.24-2.58(22H, m), 2.82-3.24(24H, m)                                           3.49-3.97(1H, m), 4.22(1H, s), 4.41 (1H,                                       d), 7.04-7.52(9H, m)                             136                                                                               "  "      2 5 pale                                                                               125-129                                                                             503 1.07-2.65(24H, m), 2.86-3.21(2H, m)                               yellow       3.42-3.98(1H, m), 4.21(1H, s), 4.47                               crystals     (1H, d), 7.04-7.57(9H, m)                        137                                                                               "  "      2 7 pale                                                                               116-122                                                                             531 1.10-2.64(28H, m), 2.79-3.24(2H, m)                               brown        3.49-4.00(1H, b), 4.22(1H, s), 4.49                               crystals     (1H, d), 7.04-7.56(9H, m)                        138                                                                               "  "      2 8 pale                                                                               109-112                                                                             545 0.98-2.46(30H, m), 2.64-3.03(2H, m)                               brown        3.28-3.80(1H, m), 4.06(1H, s), 4.31                               crystals     (1H, d), 6.94-7.47(9H, m)                        139                                                                               3-Cl                                                                              "      2 6 yellow                                                                             115-120                                                                             517 1.14-2.62(26H, m), 2.80-3.20(2H, m)                               crystals     3.43-3.87(1H, m), 4.12-4.45(1H, b)                                             4.20(1H, s), 7.03-7.51(9H, m)                    140                                                                               2-Cl                                                                              "      2 6 color-                                                                             108-115                                                                             517 1.12-2.63(26H, m), 2.72-3.15(2H, m)                               less         3.42-3.88(1H, m), 4.71-5.20(1H, b)                                crsytals     4.79(1H, s), 6.92-7.89(9H, m)                    141                                                                               H  "      2 6 pale                                                                               123-128                                                                             483 1.11-2.15(16H, m), 2.16-2.62(10H, m)                              yellow       2.79-3.19(2H, m), 3.46-3.87(1H, m)                                crystals     4.25(1H, s), 4.72-5.19(1H, b), 7.05-                                           7.58(10H, m)                                     __________________________________________________________________________

EXAMPLES 142 TO 149

Compounds of Table 26 below are prepared from various starting materials according to the same manner as described in Example 1 except using cyclohexylamine instead of ammonia.

                                      TABLE 26                                     __________________________________________________________________________      ##STR120##                                                                    Ex.                  m p. MS (M/                                               No.                                                                               R.sub.1                                                                           R.sub.2                                                                               a n aspect                                                                             (°C.)                                                                        Z)M.sup.+                                                                          NMR δ (CDCl.sub.3) ppm                     __________________________________________________________________________     142                                                                               4-Cl                                                                               ##STR121##                                                                           2 5 pale yellow crystals                                                               132-128                                                                             517 0.96-2.54(26H, m), 2.79-3.45(3H, m)                                            4.19(1H, s), 4.41(1H, d), 7.05-7.49 (9H,                                       m)                                               143                                                                               "  "      2 6 pale                                                                               126-131                                                                             531 0.94-2.54(28H, m), 2.81-3.33(3H, m)                               yellow       4.20(1H, s), 4.34(1H, b), 7.04-7.48                               crystals     (9H, m)                                          144                                                                               "  "      2 7 pale                                                                               119-124                                                                             545 0.96-2.55(30H, m), 2.70-3.24(3H, m)                               yellow       4.19(1H, s), 4.33(1H, d), 7.04-7.50                               crystals     (9H, m)                                          145                                                                               "  "      2 8 color-                                                                             122-126                                                                             559 1.01-2.58(32H, m), 2.83-3.34(3H, m)                               less         4.21(1H, s), 4.32(1H, d), 7.06-7.52                               crystals     (9H, m)                                          146                                                                               3-Cl                                                                              "      2 6 pale                                                                               118-124                                                                             531 0.80-2.65(28H, m), 2.79-3.17(3H, m)                               brown        4.19(1H, s), 4.31(1H, s), 7.03-7.54                               crystals     (9H, m)                                          147                                                                               2-Cl                                                                              "      2 6 pale                                                                               131-136                                                                             531 1.02-2.19(28H, m), 2.81-3.46(3H, m)                               yellow       4.30(1H, d), 4.82(1H, s), 6.99-7.92                               crystals     (9H, m)                                          148                                                                               4-F                                                                                ##STR122##                                                                           2 6 yellow crystals                                                                    115-125                                                                             516 0.94-2.70(28H, m), 2.78-3.74(3H, m)                                            4.45(1H, s), 5.18(1H, d), 6.70-8.58 (8H,                                       m)                                               149                                                                               H                                                                                  ##STR123##                                                                           2 6 pale yellow crystals                                                               127-135                                                                             497 0.96-2.09(18H, m), 2.12-2.60(10H, m)                                           2.74-3.16(2H, m), 3.31-3.74(1H, m) 4.24(1H,                                    s), 4.76(1H, d), 7.07-7.58 (10H,                 __________________________________________________________________________                                   m)                                          

EXAMPLES 150 TO 152

Compounds of Table 27 below are prepared from various starting materials according to the same manner as described in Example 1 except using dimethylamine instead of ammonia.

                                      TABLE 27                                     __________________________________________________________________________      ##STR124##                                                                    Ex.                    m.p. MS (M/                                             No.                                                                               R.sub.1                                                                           R.sub.2                                                                               a n  aspect                                                                              (°C.)                                                                        Z)M.sup.+                                                                           NMR δ(CDCl.sub.3)                       __________________________________________________________________________                                      ppm                                           150                                                                               4-Cl                                                                               ##STR125##                                                                           2 7  pale brown crystals                                                                 86-89                                                                               491  1.11-2.09(12H, m), 2.10-2.64(8H, m)                                            2.70-3.15(8H, m), 4.21(1H, s), 7.06-                                           7.55(9H, m)                                   151                                                                               "  "      2 10 pale 95-98                                                                               533  1.05-2.16(16H, m), 2.10-2.68(10H, m)                            yellow         2.71-3.29(8H, m), 4.19(1H, s), 7.03-                            crystals       7.60(9H, m)                                   152                                                                               "  "      2 12 color-                                                                              133-137                                                                             561  (CDCl.sub.3 + CD.sub.3 OD)1.17-2.12(20H,                                       m),                                                             less           2.62-3.93(18H, m), 4.45(1H, s), 7.20-                           crystals       7.92(9H, m)                                   __________________________________________________________________________

EXAMPLE 153

Preparation of potassium 6- 4-(4-chlorophenyl)phenylmethyl!-1-piperazinyl!hexylsulfonamide

6- 4-(4-Chlorophenyl)phenylmethyl!-1-piperazinyl!hexylsulfonamide prepared according to Method A is converted into potassium salt using aqueous potassium hydroxide solution or potassium tert-butoxide and recrystallized from methanol-diethyl ether to give the title compound as colorless crystals.

mp.214°-217° C.

NMR Spectrum: δ(CDCl₃) ppm: 1.12-2.08 (8H, m), 2.43-3.53 (12H, m), 4.28 (1H, s), 5.25 (1H, s), 7.01-7.42 (9H, m). 

We claim:
 1. A diazacycloalkanealkylsulfonamide compound having the following formula I: ##STR126## wherein R₁ is hydrogen atom, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, halogen atom, hydroxy, trifluoromethyl, nitro or amino; R₂ is phenyl which may optionally be substituted by one to three substituents on the phenyl ring selected from alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, halogen atom, hydroxy, trifluoromethyl, nitro and amino, or R₂ is 2-pyridyl, 3-pyridyl or 4-pyridyl; a is 2 or 3; Y is alkylene having 1 to 12 carbon atoms; and R₃ and R₄ are the same or different and are each hydrogen atom, alkyl having 1 to 4 carbon atoms, hydroxyalkyl having 1 to 4 carbon atoms or cycloalkyl having 3 to 8 carbon atoms, or phenyl which may optionally be substituted by one to three substituents on the phenyl ring selected from alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, halogen atom, hydroxy, trifluoromethyl, nitro and amino,or a pharmacologically acceptable salt thereof.
 2. The compound of formula I as claimed in claim 1 wherein R₁ is hydrogen atom, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, halogen atom, hydroxy, trifluoromethyl, nitro or amino; R₂ is unsubstituted phenyl, phenyl substituted by 1 to 2 halogen atoms, 2-pyridyl or 4-pyridyl; a is 2; Y is alkylene having 3 to 10 carbon atoms; and one of R₃ and R₄ is hydrogen atom and the other is hydrogen atom, alkyl having 1 to 4 carbon atoms, hydroxyalkyl having 1 to 4 carbon atoms, cycloalkyl having 3 to 8 carbon atoms, unsubstituted phenyl or phenyl which is substituted by one to three substituents on the phenyl ring selected from hydroxy and alkoxy having 1 to 4 carbon atoms; or both of R₃ and R₄ are alkyl having 1 to 4 carbon atoms.
 3. The compound of formula I as claimed in claim 1 wherein R₁ is hydrogen atom or halogen atom; R₂ is unsubstituted phenyl, phenyl substituted by halogen atom, 2-pyridyl or 4-pyridyl; a is 2; Y is alkylene having 3 to 10 carbon atoms; and one of R₃ and R₄ is hydrogen atom and the other is hydrogen atom, alkyl having 1 to 4 carbon atoms, hydroxyalkyl having 1 to 4 carbon atoms, cycloalkyl having 3 to 6 carbon atoms or tri(C₁ -C₄ alkoxy)-substituted phenyl; or both of R₃ and R₄ are alkyl having 1 to 4 carbon atoms.
 4. The compound as claimed in claim 3 wherein R₁ is meta- or para-halogen atom and R₂ is unsubstituted phenyl, 4-fluorophenyl, 2-pyridyl or 4-pyridyl.
 5. The compound as claimed in claim 4 wherein R₁ is meta- or para-chlorine atom; R₂ is unsubstituted phenyl.
 6. The compound as claimed in claim 4 wherein R₁ is para-fluorine atom and R₂ is 2-pyridyl.
 7. An agent for preventing or treating allergic disease comprising as an active ingredient one or more diazacycloalkanealkylsulfonamide compounds having the following formula: ##STR127## wherein R₁ is hydrogen atom, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, halogen atom, hydroxy, trifluoromethyl, nitro or amino; R₂ is phenyl which may optionally be substituted by 1 to 3 substituents on the phenyl ring selected from alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, halogen atom, hydroxy, trifluoromethyl, nitro and amino, or R₂ is 2-pyridyl, 3-pyridyl or 4-pyridyl; a is 2 or 3; Y is alkylene having 1 to 12 carbon atoms; and R₃ and R₄ are the same or different and are each hydrogen atom, alkyl having 1 to 4 carbon atoms, hydroxyalkyl having 1 to 4 carbon atoms or cycloalkyl having 3 to 8 carbon atoms, or phenyl which may optionally be substituted by 1 to 3 substituents on the phenyl ring selected from alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, halogen atom, hydroxy, trifluoromethyl, nitro and amino,or a pharmacologically acceptable salt thereof, in combination with a pharmaceutically acceptable carrier.
 8. A method for treatment or proplyaxis of an allergic disease comprising administering to a person an effective amount of the compound of claim
 1. 9. The method as claimed in claim 8 wherein the allergic disease is bronchial asthma, allergic rhinitis, atopic dermatitis, or urticaria. 